Literature

Abstract

Two new taxol analogs 6 and 10 have been prepared from baccatin III (1) and taxol (7a), respectively. Like taxol, both compounds were found to promote microtubule formation and stabilization, although they were less active than taxol. Both 6 and 10 exhibited cytotoxicity against J774.2 cells; 6 was ~60-fold less active and 10 was -15-fold less active.

DOI： 10.1016/S0960-894X(97)00337-5

Synthesis of novel taxol analogs and evaluation of their biological activities

Bioorganic & Medicinal Chemistry Letters 1997.0

Novel Biologically Active Taxol Analogues: Baccatin III 13-(N-(p-chlorobenzoyl)-(2′R,3′S)-3′-phenylisoserinate) and Baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-chlorophenyl)isoserinate)

Bioorganic & Medicinal Chemistry Letters 1992.0

Semisynthesis and biological activity of taxol analogues: baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-tolyl)isoserinate), baccatin III 13-(N-(p-toluoyl)-2′R,3′S)-3′-phenylisoserinate), baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-trifluoromethylphenyl)isoserinate), and baccatin III 13-(N-(p-trifluoromethylbenzoyl)-(2′R,3′S)-3′-phenylisoserinate)

Bioorganic & Medicinal Chemistry Letters 1992.0

4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation

Journal of Medicinal Chemistry 1994.0

Synthesis and biology of substituted 3′-phenyl taxol analogues

Bioorganic & Medicinal Chemistry Letters 1994.0

The first synthesis of a C-9 carbonyl modified baccatin III derivative and its conversion to novel taxol® and taxotere® analogues