Novel diarylsulfonylurea derivatives as potent antimitotic agents

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

A novel series of diarylsulfonylurea derivatives were synthesized and evaluated for interaction with tubulin and for cytotoxicity against human cancer cell lines. These derivatives demonstrated good inhibitory activity against tubulin polymerization, which was well correlated with promising antiproliferative activity as well as G2/M phase cell cycle arrest. Furthermore, several compounds were also efficacious against multidrug-resistant cancer cells, which are resistant to many other known microtubule inhibitors.

Knowledge Graph

Similar Paper

Novel diarylsulfonylurea derivatives as potent antimitotic agents
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthetic 2-Aroylindole Derivatives as a New Class of Potent Tubulin-Inhibitory, Antimitotic Agents
Journal of Medicinal Chemistry 2001.0
Design, synthesis, and biological evaluation of novel N-γ-carboline arylsulfonamides as anticancer agents
Bioorganic & Medicinal Chemistry 2010.0
Synthesis, anti-cancer evaluation of benzenesulfonamide derivatives as potent tubulin-targeting agents
European Journal of Medicinal Chemistry 2016.0
Synthesis, characterization and in vitro biological evaluation of some novel diarylsulfonylureas as potential cytotoxic and antimicrobial agents
Bioorganic & Medicinal Chemistry Letters 2012.0
Sulfonate Derivatives of Naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-Anthracenone as Highly Active Antimicrotubule Agents. Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization
Journal of Medicinal Chemistry 2007.0
Synthesis and biological evaluation of novel indole derivatives containing sulfonamide scaffold as potential tubulin inhibitor
MedChemComm 2016.0
Synthesis and cytotoxic activity of N-(2-pyridylsulfenyl)urea derivatives. A new class of potential antineoplastic agents
Bioorganic & Medicinal Chemistry Letters 1999.0
Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines
Bioorganic & Medicinal Chemistry Letters 2006.0
Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors
Bioorganic & Medicinal Chemistry 2013.0