Deoxyribonucleoside 2‘- or 3‘-Mixed Disulfides:  Prodrugs To Target Ribonucleotide Reductase and/or To Inhibit HIV Reverse Transcription

Deoxyribonucleoside 2‘- or 3‘-Mixed Disulfides:  Prodrugs To Target Ribonucleotide Reductase and/or To Inhibit HIV Reverse Transcription Anti-retroviral and cytostatic activity of 2′,3′-dideoxyribonucleoside 3′-disulfides Mononucleoside phosphorodithiolates as mononucleotide prodrugs 2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase Nucleoside Diphosphate Prodrugs: Nonsymmetric DiPPro-Nucleotides Diaryl phosphate derivatives act as pro-drugs of AZT with reduced cytotoxicity compared to the parent nucleoside Synthesis, antiretrovirus effects and phosphorylation kinetics of 3'-isocyano-3'-deoxythymidine and 3'-isocyano-2',3'-dideoxyuridine Design, synthesis, and biological evaluation of novel iso-d-2′,3′-dideoxy-3′-fluorothianucleoside derivatives Synthesis and anti-HIV activity of 4'-thio-2',3'-dideoxynucleosides S-Acyl-2-thioethyl Phosphoramidate Diester Derivatives as Mononucleotide Prodrugs