2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

2-(Anilino)imidazolines were identified as novel human 5-HT(1D) receptor ligands, but offered no particular advantage over previously reported 2-(benzyl)imidazolines. Pharmacokinetic and functional data were obtained for selected 2-(benzyl)imidazoline derivatives.

Knowledge Graph

Similar Paper

2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands
Bioorganic & Medicinal Chemistry Letters 2004.0
Benzylimidazolines as h5-HT<sub>1B/1D</sub> Serotonin Receptor Ligands: A Structure−Affinity Investigation
Journal of Medicinal Chemistry 1998.0
Benzimidazole, Benzoxazole and Benzothiazole Derivatives as 5HT2B Receptor Ligands. Synthesis and Preliminary Pharmacological Evaluation
Medicinal Chemistry Research 2005.0
Design and Synthesis of Novel Arylpiperazine Derivatives Containing the Imidazole Core Targeting 5-HT<sub>2A</sub> Receptor and 5-HT Transporter
Journal of Medicinal Chemistry 2011.0
New imidazoline/α2-adrenoceptors affecting compounds—4(5)-(2-aminoethyl)imidazoline (dihydrohistamine) derivatives. Synthesis and receptor affinity studies
Bioorganic &amp; Medicinal Chemistry 2011.0
Synthesis of New Arylpiperazinylalkylthiobenzimidazole, Benzothiazole, or Benzoxazole Derivatives as Potent and Selective 5-HT<sub>1A</sub> Serotonin Receptor Ligands
Journal of Medicinal Chemistry 2008.0
Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives. Novel 5-HT1A receptor agonist with potential antidepressant and anxiolytic activity
European Journal of Medicinal Chemistry 2010.0
Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands
Bioorganic &amp; Medicinal Chemistry Letters 1991.0
Benzofuran bioisosteres of hallucinogenic tryptamines
Journal of Medicinal Chemistry 1992.0
Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies
Journal of Medicinal Chemistry 1988.0