Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands

Bioorganic & Medicinal Chemistry Letters
1991.0

Abstract

Derivatives of benzimidazole (I), benzimidazolone (II), benzimidazolethione (III), 2,3-dihydroxyquinoxaline (IV) and the noncyclic acetamide (V) and trifluoroacetamide (VI) of the corresponding 1,2-phenylenediamine were synthesized and tested for DA-ergic activity. III and IV had a moderate affinity for the D2 receptors of the bovine caudate nucleus.

Knowledge Graph

Similar Paper

Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands
Bioorganic & Medicinal Chemistry Letters 1991.0
Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent: benzothiazol-2-one 7-ethylamines
Journal of Medicinal Chemistry 1987.0
Synthesis and adrenergic activity of benzimidazole bioisosteres of norepinephrine and isoproterenol
Journal of Medicinal Chemistry 1978.0
Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands
Journal of Medicinal Chemistry 1988.0
Synthesis of 2-(alkylamino)-5,6- and -6,7-dihydroxy-3,4-dihydroquinazolines and evaluation as potential dopamine agonists
Journal of Medicinal Chemistry 1982.0
Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI
Bioorganic & Medicinal Chemistry 2010.0
Synthesis and dopaminergic activity of a series of new 1-aryl tetrahydroisoquinolines and 2-substituted 1-aryl-3-tetrahydrobenzazepines
Bioorganic Chemistry 2018.0
Binding and Preliminary Evaluation of 5-Hydroxy- and 10-Hydroxy-2,3,12,12a-tetrahydro-1H-[1]benzoxepino[2,3,4-ij]isoquinolines as Dopamine Receptor Ligands
Journal of Medicinal Chemistry 2000.0
N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines:  Synthesis and Adrenergic and Dopaminergic Activity Studies
Journal of Medicinal Chemistry 1998.0
Synthesis and pharmacological characterization of 2-(4-chloro-3-hydroxyphenyl)ethylamine and N,N-dialkyl derivatives as dopamine receptor ligands
Journal of Medicinal Chemistry 1992.0