Identification of antitumor activity of pyrazole oxime ethers

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15.

Knowledge Graph

Similar Paper

Identification of antitumor activity of pyrazole oxime ethers
Bioorganic & Medicinal Chemistry Letters 2005.0
Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents
European Journal of Medicinal Chemistry 2012.0
Antimitotic agents: structure-activity studies with some pyridine derivatives
Journal of Medicinal Chemistry 1992.0
Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents
Bioorganic & Medicinal Chemistry Letters 2016.0
Synthesis of novel pyrazolo[3,4-d]pyrimidine derivatives as potential anti-breast cancer agents
European Journal of Medicinal Chemistry 2012.0
Antitumor Agents. 5. Synthesis, Structure−Activity Relationships, and Biological Evaluation of Dimethyl-5H-pyridophenoxazin-5-ones, Tetrahydro-5H-benzopyridophenoxazin-5-ones, and 5H-Benzopyridophenoxazin-5-ones with Potent Antiproliferative Activity
Journal of Medicinal Chemistry 2006.0
One-pot, four-component synthesis of novel cytotoxic agents 1-(5-aryl-1,3,4-oxadiazol-2-yl)-1-(1H-pyrrol-2-yl)methanamines
European Journal of Medicinal Chemistry 2014.0
Synthesis and bioactivities of novel pyrazole oxime derivatives containing a 1,2,3-thiadiazole moiety
Bioorganic & Medicinal Chemistry Letters 2016.0
Synthesis of new pyrazolo[5,1-c][1,2,4] benzotriazines, pyrazolo[5,1-c]pyrido[4,3-e][1,2,4] triazines and their open analogues as cytotoxic agents in normoxic and hypoxic conditions
Bioorganic & Medicinal Chemistry 2008.0
Synthesis of novel pyrazole and pyrimidine derivatives bearing sulfonamide moiety as antitumor and radiosensitizing agents
Medicinal Chemistry Research 2012.0