Synthesis of selective SRPK-1 inhibitors: Novel tricyclic quinoxaline derivatives

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

SR protein-specific kinase-1 (SRPK-1) has been identified as a validated target for hepatitis B virus (HBV). A series of novel tricyclic quinoxaline derivatives was designed and synthesised as potential kinase inhibitory antiviral agents and was found to be active and selective for SRPK-1 kinase. Most of these novel compounds have drug-like properties according to experimentally determined LogP and LogS values.

Knowledge Graph

Similar Paper

Synthesis of selective SRPK-1 inhibitors: Novel tricyclic quinoxaline derivatives
Bioorganic & Medicinal Chemistry Letters 2005.0
Synthesis and anti-hepatitis B virus evaluation of novel ethyl 6-hydroxyquinoline-3-carboxylates in vitro
Bioorganic & Medicinal Chemistry 2008.0
Structure–activity relationships study of 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl) quinolin-2(1H)-one derivatives as novel non-nucleoside anti-hepatitis B virus agents
European Journal of Medicinal Chemistry 2011.0
Quinoline tricyclic derivatives. Design, synthesis and evaluation of the antiviral activity of three new classes of RNA-dependent RNA polymerase inhibitors
Bioorganic & Medicinal Chemistry 2011.0
Tryptamine derivatives as novel non-nucleosidic inhibitors against hepatitis B virus
Bioorganic & Medicinal Chemistry 2011.0
Design, Synthesis, and Antihepatitis B Virus Activities of Novel 2-Pyridone Derivatives
Journal of Medicinal Chemistry 2010.0
2,4-Diaryl-4,6,7,8-tetrahydroquinazolin-5(1H)-one derivatives as anti-HBV agents targeting at capsid assembly
Bioorganic & Medicinal Chemistry Letters 2010.0
Design and synthesis of pyridine-pyrazole-sulfonate derivatives as potential anti-HBV agents
MedChemComm 2016.0
Assessment of quinazolinone derivatives as novel non-nucleoside hepatitis B virus inhibitors
European Journal of Medicinal Chemistry 2019.0
Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus
Bioorganic & Medicinal Chemistry 2010.0