2,4-Diaryl-4,6,7,8-tetrahydroquinazolin-5(1H)-one derivatives as anti-HBV agents targeting at capsid assembly

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

A series of novel 2,4-diaryl-4,6,7,8-tetrahydroquinazolin-5(1H)-one derivatives were designed and synthesized as potent inhibitors of HBV capsid assembly. These compounds arose from efforts to rigidify an earlier series of heteroaryldihydropyrimidines (HAPs), and compounds 12, 13, 20, 24, 30 and 32 showed potent inhibition of HBV capsid assembly, especially 24 with IC(50) value at sub-micromolar range.

Knowledge Graph

Similar Paper

2,4-Diaryl-4,6,7,8-tetrahydroquinazolin-5(1H)-one derivatives as anti-HBV agents targeting at capsid assembly
Bioorganic & Medicinal Chemistry Letters 2010.0
A new series of HAPs as anti-HBV agents targeting at capsid assembly
Bioorganic & Medicinal Chemistry Letters 2014.0
Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors
European Journal of Medicinal Chemistry 2020.0
Assessment of quinazolinone derivatives as novel non-nucleoside hepatitis B virus inhibitors
European Journal of Medicinal Chemistry 2019.0
Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives
Bioorganic & Medicinal Chemistry Letters 2008.0
Structure–activity relationships study of 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl) quinolin-2(1H)-one derivatives as novel non-nucleoside anti-hepatitis B virus agents
European Journal of Medicinal Chemistry 2011.0
Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors
Bioorganic & Medicinal Chemistry Letters 2017.0
Discovery of Novel Pyrimidine-Based Capsid Assembly Modulators as Potent Anti-HBV Agents
Journal of Medicinal Chemistry 2021.0
Discovery of novel quinazolinone derivatives as potential anti-HBV and anti-HCC agents
European Journal of Medicinal Chemistry 2020.0
Synthesis and anti-hepatitis B virus evaluation of novel ethyl 6-hydroxyquinoline-3-carboxylates in vitro
Bioorganic & Medicinal Chemistry 2008.0