Studies on the structure–activity relationship of 2′,6′-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H–Dmt–NH–CH3

Studies on the structure–activity relationship of 2′,6′-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H–Dmt–NH–CH3 [Dmt1]DALDA analogues modified with tyrosine analogues at position 1 Discovery of a Potent and Efficacious Peptide Derivative for δ/μ Opioid Agonist/Neurokinin 1 Antagonist Activity with a 2′,6′-Dimethyl-<scp>l</scp>-Tyrosine: In vitro, In vivo, and NMR-Based Structural Studies Evolution of the Dmt-Tic Pharmacophore:  N-Terminal Methylated Derivatives with Extraordinary δ Opioid Antagonist Activity Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2 Effect of Lysine at C-Terminus of the Dmt-Tic Opioid Pharmacophore Systemic analgesic activity and .delta.-opioid selectivity in [2,6-dimethyl-Tyr1, D-Pen2, D-Pen5]enkephalin Dermorphin tetrapeptide analogues with 2′,6′-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high μ opioid receptor binding and biological activities1 Synthesis and Characterization of Potent and Selective μ-Opioid Receptor Antagonists, [Dmt, <scp>d</scp>-2-Nal⁴]endomorphin-1 (Antanal-1) and [Dmt¹, <scp>d</scp>-2-Nal⁴]endomorphin-2 (Antanal-2) Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity