A Peptide Nucleic Acid−Neamine Conjugate That Targets and Cleaves HIV-1 TAR RNA Inhibits Viral Replication

A Peptide Nucleic Acid−Neamine Conjugate That Targets and Cleaves HIV-1 TAR RNA Inhibits Viral Replication Neamine dimers targeting the HIV-1 TAR RNA Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA–protein interactions derived from HIV-1 activators Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA Inhibition of an HIV-1 Tat-derived peptide binding to TAR RNA by aminoglycoside antibiotics Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1 Recognition of HIV-TAR RNA using neomycin–benzimidazole conjugates Recognition of HIV TAR RNA by triazole linked neomycin dimers Multivalent amino sugars to recognize different TAR RNA conformations Synthesis and evaluation of novel neamine derivatives effectively targeting to RNA