New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics

Bioorganic & Medicinal Chemistry Letters
2007.0

Abstract

Substitution of phenyl oxazolidinones with carbon-linked azoles resulted in the discovery of a new class of potent oxazolidinones that have excellent Gram-positive activity. In addition, replacement of the C-5 acetamide side chains with a 4-methyl triazole diminished monoamine oxidase activity. The synthesis and biological evaluation of these compounds are reported.

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