Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

Starting from 10-deacetylbaccatin III (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes.

Knowledge Graph

Similar Paper

Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390
Bioorganic & Medicinal Chemistry Letters 2005.0
Synthesis and biological activity of 3′-alkyl- and 3′-alkenyl-3′-dephenyldocetaxels
Bioorganic & Medicinal Chemistry Letters 1994.0
Syntheses and Structure−Activity Relationships of Taxoids Derived from 14β-Hydroxy-10-deacetylbaccatin III
Journal of Medicinal Chemistry 1997.0
Syntheses and biological evaluation of C-3′-N-acyl modified taxane analogues from 1-deoxybaccatin-VI
European Journal of Medicinal Chemistry 2015.0
Novel Biologically Active Taxol Analogues: Baccatin III 13-(N-(p-chlorobenzoyl)-(2′R,3′S)-3′-phenylisoserinate) and Baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-chlorophenyl)isoserinate)
Bioorganic & Medicinal Chemistry Letters 1992.0
Synthesis and biological activity of C-7, C-9 and C-10 modified taxane analogues from 1-deoxybaccatin VI
Bioorganic & Medicinal Chemistry 2020.0
Synthesis and biological activity of 14-hydroxydocetaxel
Bioorganic & Medicinal Chemistry Letters 1994.0
Synthesis and Biological Evaluation of 2‘-Methyl Taxoids Derived from Baccatin III and 14β-OH-Baccatin III 1,14-Carbonate
Journal of Medicinal Chemistry 2003.0
4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation
Journal of Medicinal Chemistry 1994.0
New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 3
Bioorganic & Medicinal Chemistry Letters 2003.0