Privileged structure-based quinazolinone natural product-templated libraries: Identification of novel tubulin polymerization inhibitors

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

A focused quinazolinone natural product-templated library was designed and synthesized. Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization. The results suggested that 2 could be a privileged substructure.

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