Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

A few substituted piperazinylphenyloxazolidinone compounds 6-13 having substitution on the distant nitrogen atom of piperazine ring scaffold have been synthesized and evaluated for their antibacterial activity in Gram-positive bacteria. A few compounds showed superior in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Streptococcus pyogenes than linezolid and eperezolid.

Knowledge Graph

Similar Paper

Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials
Bioorganic & Medicinal Chemistry Letters 2006.0
Novel 4-N-substituted aryl but-3-ene-1,2-dione derivatives of piperazinyloxazolidinones as antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2009.0
Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents
Bioorganic & Medicinal Chemistry Letters 2004.0
Piperazinyl Oxazolidinone Antibacterial Agents Containing a Pyridine, Diazene, or Triazene Heteroaromatic Ring
Journal of Medicinal Chemistry 1998.0
Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones
Bioorganic & Medicinal Chemistry Letters 2007.0
Synthesis and in vitro antibacterial activities of novel oxazolidinones☆
European Journal of Medicinal Chemistry 2008.0
Novel piperidinyloxy oxazolidinone antimicrobial agents
Bioorganic & Medicinal Chemistry Letters 2001.0
Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial
Bioorganic & Medicinal Chemistry Letters 2009.0
Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones
Bioorganic & Medicinal Chemistry Letters 2013.0