New Potent P-Glycoprotein Inhibitors Carrying a Polycyclic Scaffold

Journal of Medicinal Chemistry
2006.0

Abstract

New pentacyclic inhibitors of the P-glycoprotein carrying nitrogen-containing alkyl chains were synthesized and evaluated for MDR reverting activity on mouse lymphoma cells infected with pHa MDR1/A retrovirus. The activity of the compounds proved to be up to 5-fold higher than verapamil, used as reference compound.

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