The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-α production

The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-α production The development of new bicyclic pyrazole-based cytokine synthesis inhibitors The development of monocyclic pyrazolone based cytokine synthesis inhibitors Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase From Imidazoles to Pyrimidines:  New Inhibitors of Cytokine Release The development of new triazole based inhibitors of tumor necrosis factor-α (TNF-α) production Substituted Xanthines, Pteridinediones, and Related Compounds as Potential Antiinflammatory Agents. Synthesis and Biological Evaluation of Inhibitors of Tumor Necrosis Factor α A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: Part 1 Synthesis and bioactivities of novel bicyclic thiophenes and 4,5,6,7-tetrahydrothieno[2,3-c]pyridines as inhibitors of tumor necrosis factor-α (TNF-α) production