Synthesis and antibacterial activity of C12 des-methyl ketolides

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

Synthesis of C(12) des-methyl ketolide is developed featuring an intramolecular epoxide formation/elimination process to establish the C(12) stereocenter. These ketolides are potent against several key respiratory pathogens, including erythromycin resistant erm- and mef-containing strains of Streptococcus pneumoniae.

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