Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

European Journal of Medicinal Chemistry
2010.0

Abstract

A series of C-12 pyrazolinyl spiro ketolide derivatives were designed and synthesized. The C-12 modifications involved replacing the natural C-12 methyl group in clarithromycin core with different pyrazolinyl spiros via chemical synthesis. Potential anti-bacterial activities against both erythromycin-susceptible and erythromycin-resistant bacteria were reported.

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