Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

PPAR ligands with varied subtype selectivity have been synthesized using an achiral aminomethyl dihydrocinnamate template. Several compounds in this series have demonstrated potent plasma glucose and triglyceride lowering capability in rodent models of type 2 diabetes.

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