In Vitro Activity of the Oxazolidinone RWJ-416457 against Linezolid-Resistant and -Susceptible Staphylococci and Enterococci

Antimicrobial Agents and Chemotherapy
2007.0

Abstract

RWJ-416457, a novel oxazolidinone, had modal MICs of 0.5 to 1 microg/ml for linezolid-susceptible staphylococci and enterococci, versus linezolid MICs for these organisms of 1 or 2 microg/ml. RWJ-416457 MICs for mutants with 23S rRNA mutations were 2 to 32 microg/ml, versus linezolid MICs of 8 to 64 microg/ml; actual values reflected the proportion of gene copies mutated.

Knowledge Graph

Similar Paper

In Vitro Activity of the Oxazolidinone RWJ-416457 against Linezolid-Resistant and -Susceptible Staphylococci and Enterococci
Antimicrobial Agents and Chemotherapy 2007.0
In Vitro Antibacterial Activity of the Pyrrolopyrazolyl-Substituted Oxazolidinone RWJ-416457
Antimicrobial Agents and Chemotherapy 2007.0
In Vivo Activity of the Pyrrolopyrazolyl-Substituted Oxazolidinone RWJ-416457
Antimicrobial Agents and Chemotherapy 2009.0
Pharmacokinetic-Pharmacodynamic Modeling of the In Vitro Activities of Oxazolidinone Antimicrobial Agents against Methicillin-ResistantStaphylococcus aureus
Antimicrobial Agents and Chemotherapy 2009.0
In Vitro Activities of the Rx-01 Oxazolidinones against Hospital and Community Pathogens
Antimicrobial Agents and Chemotherapy 2008.0
Mutations in Ribosomal Protein L3 Are Associated with Oxazolidinone Resistance in Staphylococci of Clinical Origin
Antimicrobial Agents and Chemotherapy 2009.0
Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones
Bioorganic & Medicinal Chemistry Letters 2007.0
Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives
Bioorganic & Medicinal Chemistry Letters 2004.0
Activity of Linezolid in anIn VitroPharmacokinetic-Pharmacodynamic Model Using Different Dosages andStaphylococcus aureusandEnterococcus faecalisStrains with and without a Hypermutator Phenotype
Antimicrobial Agents and Chemotherapy 2010.0
Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2003.0