α-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents

European Journal of Medicinal Chemistry
2007.0

Abstract

In a program to identify new anti-ulcer compounds, a series of N-acyl derivatives of alpha-amino acids were screened for their in vitro H(+)/K(+) ATPase inhibitory activity, and in vivo efficacy in Pylorus ligation model. 3D-QSAR studies were carried out and a representative compound 13 was studied for the nature of its proton pump inhibition.

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