Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers

Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers Discovery of a Novel Pyrrole Derivative 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Fumarate (TAK-438) as a Potassium-Competitive Acid Blocker (P-CAB) Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action Synthesis of (aryloxy)alkylamines. I. Novel antisecretory agents with H+K+-ATPase inhibitory activity (H+, K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate Nicotinamide Derivatives as a New Class of Gastric H⁺/K⁺-ATPase Inhibitors. 1. Synthesis and Structure−Activity Relationships of N-Substituted 2-(Benzhydryl- and benzylsulfinyl)nicotinamides α-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 5. Substituted 2,4-Diaminoquinazolines and Thienopyrimidines Anti-Helicobacter pyloriAgents. 1. 2-(Alkylguanidino)-4-furylthiazoles and Related Compounds Syntheses and gastric acid antisecretory properties of the H2-receptor antagonist N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]thieno[3,4-d]isothiazol-3-amine 1,1-dioxide and related derivatives