Synthesis, in vitro antibacterial and antifungal evaluations of 2-amino-4-(1-naphthyl)-6-arylpyrimidines

European Journal of Medicinal Chemistry
2007.0

Abstract

A series of 2-amino-4-(1-naphthyl)-6-arylpyrimidines have been synthesized and characterized by IR, NMR, MS, elemental analyses and evaluated for in vitro antibacterial and antifungal activities. Some of the compounds were found to be active against a limited panel of bacteria and fungi. In particular, compounds 4b and 4e were found to be the most effective analogs against the tested bacterial and fungal strains.

Knowledge Graph

Similar Paper

Synthesis, in vitro antibacterial and antifungal evaluations of 2-amino-4-(1-naphthyl)-6-arylpyrimidines
European Journal of Medicinal Chemistry 2007.0
Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides
European Journal of Medicinal Chemistry 2010.0
Synthesis and evaluation of a series of aminocyanopyridines as antimicrobial agents
Medicinal Chemistry Research 2011.0
Synthesis and biological evaluation of novel (l)-α-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2005.0
Synthesis and characterization of new types of 2-(6-methoxy-2-naphthyl)propionamide derivatives as potential antibacterial and antifungal agents
Medicinal Chemistry Research 2013.0
Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents
Bioorganic & Medicinal Chemistry Letters 2011.0
Synthesis and Antifungal Activities of Some Novel Pyrimidine Derivatives
Molecules 2011.0
Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents
Bioorganic & Medicinal Chemistry Letters 2005.0
Synthesis of promising antimicrobial agents: a novel series of N-(4-(2,6-dichloroquinolin-3-yl)-6-(aryl)pyrimidin-2-yl)-2-morpholinoacetamides
Medicinal Chemistry Research 2013.0
Synthesis and in vitro microbiological evaluation of novel 4-aryl-5-isopropoxycarbonyl-6-methyl-3,4-dihydropyrimidinones
European Journal of Medicinal Chemistry 2010.0