Synthesis and antimalarial activity of new 1,12-bis(N,N′-acetamidinyl)dodecane derivatives

Bioorganic & Medicinal Chemistry Letters
2007.0

Abstract

Amidoxime and O-substituted derivatives of the bis-alkylamidine 1,12-bis(N,N'-acetamidinyl)dodecane were synthesized and evaluated as in vitro and in vivo antimalarial prodrugs. The bis-O-methylsulfonylamidoxime 8 and the bis-oxadiazolone 9 derivatives show relatively potent antimalarial activity after oral administration.

Knowledge Graph

Similar Paper

Synthesis and antimalarial activity of new 1,12-bis(N,N′-acetamidinyl)dodecane derivatives
Bioorganic & Medicinal Chemistry Letters 2007.0
Synthesis and Antimalarial Activity of 2-Guanidino-4-oxoimidazoline Derivatives
Journal of Medicinal Chemistry 2011.0
Evaluation of amidoxime derivatives as prodrug candidates of potent bis-cationic antimalarials
Bioorganic & Medicinal Chemistry Letters 2019.0
Synthesis, DNA Affinity, and Antiprotozoal Activity of Linear Dications:  Terphenyl Diamidines and Analogues
Journal of Medicinal Chemistry 2006.0
Synthesis, characterization, molecular docking and in vitro antimalarial properties of new carboxamides bearing sulphonamide
European Journal of Medicinal Chemistry 2017.0
Disulfide Prodrugs of Albitiazolium (T3/SAR97276): Synthesis and Biological Activities
Journal of Medicinal Chemistry 2012.0
Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin
Bioorganic & Medicinal Chemistry Letters 2009.0
Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes
European Journal of Medicinal Chemistry 2009.0
Acyloxybenzyl and Alkoxyalkyl Prodrugs of a Fosmidomycin Surrogate as Antimalarial and Antitubercular Agents
ACS Medicinal Chemistry Letters 2018.0
New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities
Bioorganic & Medicinal Chemistry Letters 2011.0