Engineering small molecule specificity in nearly identical cellular environments

Engineering small molecule specificity in nearly identical cellular environments Analogs of methotrexate Methotrexate analogs. 15. A methotrexate analogue designed for active-site-directed irreversible inactivation of dihydrofolate reductase Synthesis of methotrexate-antibody conjugates by regiospecific coupling and assessment of drug and antitumor activities Methotrexate analogs. 14. Synthesis of new .gamma.-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents Synthesis and Biological Evaluation of<scp>dl</scp>-4,4-Difluoroglutamic Acid and<scp>dl</scp>-γ,γ-Difluoromethotrexate Tight binding ligand approach to oligosaccharide-grafted protein Methotrexate analogs. 22. Synthesis, dihydrofolate reductase affinity, cytotoxicity, and in vivo antitumor activity of some putative degradation products of methotrexate-poly(L-lysine) conjugates Methotrexate analogs. 29. Effect of .gamma.-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition Methotrexate γ-hydroxamate derivatives as potential dual target antitumor drugs