Tight binding ligand approach to oligosaccharide-grafted protein

Tight binding ligand approach to oligosaccharide-grafted protein Methotrexate analogs. 15. A methotrexate analogue designed for active-site-directed irreversible inactivation of dihydrofolate reductase Engineering small molecule specificity in nearly identical cellular environments Computational Predictions of Binding Affinities to Dihydrofolate Reductase:  Synthesis and Biological Evaluation of Methotrexate Analogues Synthesis of methotrexate-antibody conjugates by regiospecific coupling and assessment of drug and antitumor activities Methotrexate analogs. 14. Synthesis of new .gamma.-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase Synthesis and Biological Evaluation of<scp>dl</scp>-4,4-Difluoroglutamic Acid and<scp>dl</scp>-γ,γ-Difluoromethotrexate Lysine and ornithine analogs of methotrexate as inhibitors of dihydrofolate reductase Methotrexate analogs. 22. Synthesis, dihydrofolate reductase affinity, cytotoxicity, and in vivo antitumor activity of some putative degradation products of methotrexate-poly(L-lysine) conjugates