Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs

Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs Heteroaromatic Moieties in the Sphingosine Backbone of α-Galactosylceramides for Noncovalent Interactions with CD1d Design, synthesis, and evaluation of α-galactopyranosylceramide mimics promoting Th2 cytokines production Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile Design and Evaluation of ω-Hydroxy Fatty Acids Containing α-GalCer Analogues for CD1d-Mediated NKT Cell Activation Development of α-GalCer Analogues with an α-Fluorocarbonyl Moiety as Th2-Selective Ligands of CD1d Improved Th17 Selectivity of α-Galactosylceramide via Noncovalent Interactions with Diether Moiety Synthesis of 5-Thio-α-GalCer Analogues with Fluorinated Acyl Chain on Lipid Residue and Their Biological Evaluation Introduction of aromatic group on 4′-OH of α-GalCer manipulated NKT cell cytokine production Synthesis and biological activities of amino acids functionalized α-GalCer analogues