Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors Activation of the γ-Aminobutyric Acid Type B (GABA_B) Receptor by Agonists and Positive Allosteric Modulators Discovery of a Negative Allosteric Modulator of GABA_B Receptors Synthesis and Pharmacological Characterization of 2-(Acylamino)thiophene Derivatives as Metabolically Stable, Orally Effective, Positive Allosteric Modulators of the GABA_B Receptor Design and identification of a novel, functionally subtype selective GABA_Apositive allosteric modulator (PF-06372865). Developing dual functional allosteric modulators of GABAA receptors Use of bicuculline, a GABA antagonist, as a template for the development of a new class of ligands showing positive allosteric modulation of the GABAA receptor Synthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABA_B) Receptor Agonists as Gastroesophageal Reflux Inhibitors Synthesis and pharmacological evaluation of .gamma.-aminobutyric acid analogs. New ligand for GABAB sites Synthesis and in Vitro Activity of 3β-Substituted-3α-hydroxypregnan-20-ones:  Allosteric Modulators of the GABA_A Receptor