Design, synthesis, and structure–activity relationship studies of new phenolic DNA gyrase inhibitors

Bioorganic & Medicinal Chemistry Letters
2007.0

Abstract

Starting from a biased needle screening hit 3a, we report herein the design and synthesis of a series of novel 2,3-dihydroisoindol-1-ones structurally related to cyclothialidine 2 with DNA gyrase inhibitory activity. In this series, some compounds exhibited promising antibacterial activity against gram-positive bacterial strains.

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