4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity

Bioorganic & Medicinal Chemistry Letters
2008.0

Abstract

Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.

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