Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities

European Journal of Medicinal Chemistry
2008.0

Abstract

For the development of novel antitumor agents, we designed and synthesized 2,6-diaryl-substituted pyridine derivatives bearing three aryl groups, which are the bioisosteres of terpyridine, and evaluated their biological activities. Most of the 18 prepared compounds showed moderate cytotoxicity against several human cancer cell lines. From the structure-activity relationships we may conclude that the number of aryl groups employed would be critical for their biological activities.

Knowledge Graph

Similar Paper

Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities
European Journal of Medicinal Chemistry 2008.0
Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-Terpyridine derivatives
Bioorganic & Medicinal Chemistry Letters 2001.0
Topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines
Bioorganic & Medicinal Chemistry 2015.0
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines
Bioorganic & Medicinal Chemistry 2010.0
Design and synthesis of novel 2′-hydroxy group substituted 2-pyridone derivatives as anticancer agents
European Journal of Medicinal Chemistry 2013.0
Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety
European Journal of Medicinal Chemistry 2012.0
Synthesis and biological evaluation of novel 1,6-diaryl pyridin-2(1H)-one analogs
European Journal of Medicinal Chemistry 2013.0
Design and synthesis of novel 5,6-disubstituted pyridine-2,3-dione-3-thiosemicarbazone derivatives as potential anticancer agents
European Journal of Medicinal Chemistry 2014.0
Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship
European Journal of Medicinal Chemistry 2011.0
Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study
European Journal of Medicinal Chemistry 2012.0