Literature

Abstract

In this work we prepared and characterized an inclusion complex of the dihydropteroate synthase inhibitor sulfadiazine (SDZ) in 2-hydroxypropyl-beta-cyclodextrin (HPBCD). From the phase-solubility diagram we observed an increase in the water solubility of the drug, calculating a binding constant of 1879M(-1). The inclusion mode involves a NH(2)-in orientation of the drug in the HPBCD cavity, according to the 2D NMR (ROESY) data and confirmed by molecular modeling using the semiempirical PM6 and RM1 methods.

DOI： 10.1016/j.bmc.2008.03.057

Sulfadiazine/hydroxypropyl-β-cyclodextrin host–guest system: Characterization, phase-solubility and molecular modeling

Bioorganic & Medicinal Chemistry 2008.0

Improvement of water solubility of non-competitive AMPA receptor antagonists by complexation with β-cyclodextrin

Bioorganic & Medicinal Chemistry 2008.0

In silico and in vitro study of epiisopiloturine/ hydroxypropyl-β-cyclodextrin inclusion complexes obtained by different methods

Journal of Drug Delivery Science and Technology 2021.0

Synthesis, characterization and in vitro release studies of a new acetazolamide–HP-β-CD–TEA inclusion complex

European Journal of Medicinal Chemistry 2008.0

Inclusion Complexation and Solubilization of Paclitaxel by Bridged Bis(β-cyclodextrin)s Containing a Tetraethylenepentaamino Spacer

Journal of Medicinal Chemistry 2003.0

Preparation, characterization, molecular modeling and In vitro activity of paclitaxel–cyclodextrin complexes