Microxine, a New cdc2 Kinase Inhibitor from the Australian Marine Sponge Microxina Species

Journal of Natural Products
2001.0

Abstract

A new purine derivative microxine (1) was isolated from the Australian marine sponge Microxina sp. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. Microxine was found to weakly inhibit cdc2 kinase activity with an IC(50) of 13 microM.

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