Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold

Bioorganic & Medicinal Chemistry
2008.0

Abstract

The aminopeptidase N (APN/CD13), overexpressed in tumor cells, plays a critical role in angiogenesis. In this study, we report the synthesis and in vitro enzyme inhibition assay of 1,3,4-thiadiazole scaffold compounds. These new compounds have potent inhibitory activities toward APN with IC(50) values in the micromol rang.

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