Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines

Bioorganic & Medicinal Chemistry Letters
2008.0

Abstract

Reaction of 6a-f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a-f in excellent yield. The newly synthesized heterocycles were characterized by IR, (1)H NMR, and mass spectral data. Compounds 7a-f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.

Knowledge Graph

Similar Paper

Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines
Bioorganic & Medicinal Chemistry Letters 2008.0
Synthesis and anti-inflammatory activity of 2-aryloxy methyl oxazolines
Bioorganic & Medicinal Chemistry Letters 2008.0
New condensed pyrroles of potential biological interest
European Journal of Medicinal Chemistry 2011.0
Studies on heterocyclic compounds. 6. Synthesis and analgesic and antiinflammatory activities of 3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives
Journal of Medicinal Chemistry 1984.0
A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: Synthesis, anti-inflammatory and antimicrobial evaluation
Bioorganic & Medicinal Chemistry Letters 2012.0
Synthesis, antiproliferative and anti-inflammatory activities of some novel 6-aryl-2-(p-(methanesulfonyl)phenyl)-4,5-dihydropyridazi-3(2H)-ones
European Journal of Medicinal Chemistry 2013.0
Synthesis and analgesic/anti-inflammatory evaluation of fused heterocyclic ring systems incorporating phenylsulfonyl moiety
Bioorganic & Medicinal Chemistry 2008.0
Synthesis, characterization and pharmacological study of 4,5-dihydropyrazolines carrying pyrimidine moiety
European Journal of Medicinal Chemistry 2012.0
Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]Pyrimidine derivatives for their anti-inflammatory and anti-microbial activities
European Journal of Medicinal Chemistry 2010.0
Synthesis, anti-inflammatory, ulcerogenic and cyclooxygenase activities of indenopyrimidine derivatives
Bioorganic & Medicinal Chemistry Letters 2016.0