Novel benzimidazole derivatives as selective CB2 agonists

Bioorganic & Medicinal Chemistry Letters
2008.0

Abstract

The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to excellent selectivity (>1000-fold) over the CB1 receptor.

Knowledge Graph

Similar Paper

Novel benzimidazole derivatives as selective CB2 agonists
Bioorganic & Medicinal Chemistry Letters 2008.0
New 1,2,3,4-tetrahydropyrrolo[3,4-b]indole derivatives as selective CB2 receptor agonists
Bioorganic & Medicinal Chemistry Letters 2007.0
Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor
European Journal of Medicinal Chemistry 2016.0
Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists
Bioorganic & Medicinal Chemistry Letters 2009.0
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists
Bioorganic & Medicinal Chemistry Letters 2007.0
Discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB2 agonists
Bioorganic & Medicinal Chemistry Letters 2009.0
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 1: Discovery of CB2 receptor selective compounds
Bioorganic & Medicinal Chemistry Letters 2007.0
Sulfamoyl benzamides as novel CB2 cannabinoid receptor ligands
Bioorganic & Medicinal Chemistry Letters 2008.0
7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as Selective CB<sub>2</sub>Cannabinoid Receptor Ligands: Structural Investigations around a Novel Class of Full Agonists
Journal of Medicinal Chemistry 2012.0
Design, Synthesis, and Biological Evaluation of New 1,8-Naphthyridin-4(1H)-on-3-carboxamide and Quinolin-4(1H)-on-3-carboxamide Derivatives as CB<sub>2</sub>Selective Agonists
Journal of Medicinal Chemistry 2006.0