Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A

Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A GPR109a agonists. Part 2: Pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a) GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole–tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b Discovery of novel pyrrole derivatives as potent agonists for the niacin receptor GPR109A Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A Agonist lead identification for the high affinity niacin receptor GPR109a