Discovery of novel pyrrole derivatives as potent agonists for the niacin receptor GPR109A

Discovery of novel pyrrole derivatives as potent agonists for the niacin receptor GPR109A Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a) Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b GPR109a agonists. Part 2: Pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a Discovery of coumarin-dihydroquinazolinone analogs as niacin receptor 1 agonist with in-vivo anti-obesity efficacy Discovery of Novel Tricyclic Full Agonists for the G-Protein-Coupled Niacin Receptor 109A with Minimized Flushing in Rats