Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones

Bioorganic & Medicinal Chemistry Letters
2008.0

Abstract

A novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors are described. The side-chain SAR against Gram-positive and Gram-negative organisms as well as DNA gyrase activity is reported.

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