Design at the atomic level: Design of biaryloxazolidinones as potent orally active antibiotics

Bioorganic & Medicinal Chemistry Letters
2008.0

Abstract

We have developed a first generation of hybrid sparsomycin-linezolid compounds into a new family of orally bioavailable biaryloxazolidinones that have activity against both linezolid-susceptible and -resistant gram-positive bacteria as well as the fastidious gram-negative bacteria Haemophilus influenzae and Moraxella catarrahalis. The convergent synthesis of these new compounds is detailed.

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