Design at the atomic level: Generation of novel hybrid biaryloxazolidinones as promising new antibiotics

Bioorganic & Medicinal Chemistry Letters
2008.0

Abstract

From the X-ray crystal structures of linezolid and the non-selective antibiotic sparsomycin, we have derived a new family of hybrid oxazolidinones. From this initial compound set we have developed a new biaryloxazolidinone scaffold that shows both potent antimicrobial activity as well as selective inhibition of ribosomal translation. The synthesis of these compounds is outlined.

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