Calmodulin inhibitory activity of the malbrancheamides and various analogs

Bioorganic & Medicinal Chemistry Letters
2008.0

Abstract

The preparation and biological activity of various structural analogs of the malbrancheamides are disclosed. The impact of indole chlorination, C-12a relative stereochemistry, and bicyclo[2.2.2]diazaoctane core oxidation state on the ability of these analogs to inhibit calmodulin dependent phosphodiesterase (PDE1) was studied, and a number of potent compounds were identified.

Knowledge Graph

Similar Paper