Hydration of Drug−DNA Complexes: Greater Water Uptake for Adriamycin Compared to Daunomycin

Hydration of Drug−DNA Complexes: Greater Water Uptake for Adriamycin Compared to Daunomycin Adriamycin analogs. 1. Preparation and antitumor evaluation of 7-O-(.beta.-D-glucosaminyl)daunomycinone and 7-O-(.beta.-D-glucosaminyl)adriamycinone and their N-trifluoroacetyl derivatives Solution studies on the complex of 4′-epiadriamycin-d-(CGATCG)2 followed by time-resolved fluorescence measurement, diffusion ordered spectroscopy and restrained molecular dynamics simulations Cellular pharmacodynamics of several anthracycline antibiotics Potential antitumor agents. 39. Anilino ring geometry of amsacrine and derivatives: relationship to DNA binding and antitumor activity Adriamycin analogs. 2. Novel anomeric ribofuranoside analogs of daunorubicin Adriamycin analogs. 3. Synthesis of N-alkylated anthracyclines with enhanced efficacy and reduced cardiotoxicity Inhibition of Topoisomerase I by Anthracycline Antibiotics: Evidence for General Inhibition of Topoisomerase I by DNA-Binding Agents Synthesis of (−)-6-(3′-aminopropyloxy)methyl-4-demethoxy-6, 7-dideoxy-daunomycinone, a new dna intercalator related to anthracyclines Interactions of antitumor drugs with natural DNA: proton NMR study of binding mode and kinetics