Inhibition of Topoisomerase I by Anthracycline Antibiotics: Evidence for General Inhibition of Topoisomerase I by DNA-Binding Agents

Inhibition of Topoisomerase I by Anthracycline Antibiotics: Evidence for General Inhibition of Topoisomerase I by DNA-Binding Agents Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans Synthesis of (−)-6-(3′-aminopropyloxy)methyl-4-demethoxy-6, 7-dideoxy-daunomycinone, a new dna intercalator related to anthracyclines New naphthacenecarboxamide antibiotics, TAN-1518 A and B, have inhibitory activity against mammalian DNA topoisomerase I. Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex Interaction of Daunomycin with Acetylated Chromatin Inhibition of Human Topoisomerases I and II by Simocyclinone D8 Synthesis, DNA Binding, and Leishmania Topoisomerase Inhibition Activities of a Novel Series of Anthra[1,2-d]imidazole-6,11-dione Derivatives 7-Azaindenoisoquinolines as Topoisomerase I Inhibitors and Potential Anticancer Agents Hydration of Drug−DNA Complexes: Greater Water Uptake for Adriamycin Compared to Daunomycin