Synthesis and antimicrobial activity of 2-alkenylchroman-4-ones, 2-alkenylthiochroman-4-ones and 2-alkenylquinol-4-ones

Bioorganic & Medicinal Chemistry
2008.0

Abstract

2-Alkenylchroman-4-ones, 2-alkenylthiochroman-4-ones, and 2-alkenylquinol-4-ones were prepared with very good regioselectivity by Me3SiOTf-mediated conjugate addition of alkenylmagnesium bromides and alkenyllithium compounds to chromones thiochromones, and quinol-4-ones. A number of products exhibit a considerable antimicrobial activity. The best activity, with respect to the spectrum of antimicrobial activity, was observed for 2-vinylchroman-4-ones containing an unsubstituted vinyl group and a chloride group located at the chromanone moiety.

Knowledge Graph

Similar Paper

Synthesis and antimicrobial activity of 2-alkenylchroman-4-ones, 2-alkenylthiochroman-4-ones and 2-alkenylquinol-4-ones
Bioorganic & Medicinal Chemistry 2008.0
Synthesis and antimicrobial activity of some new 4-triazolylmethoxy-2H-chromen-2-one derivatives
Medicinal Chemistry Research 2012.0
Synthesis of antimicrobial 2,9,10-trisubstituted-6-oxo-7,12-dihydro-chromeno[3,4-b]quinoxalines
Bioorganic & Medicinal Chemistry Letters 2006.0
Regioselective synthesis of 3-benzyl substituted pyrimidino chromen-2-ones and evaluation of anti-microbial and anti-biofilm activities
Bioorganic & Medicinal Chemistry Letters 2014.0
Synthesis of a new series of 2-(2-oxo-2H-chromen-3-yl)-5H-chromeno[4,3-b]pyridin-5-ones by two facile methods and evaluation of their antimicrobial activity
Medicinal Chemistry Research 2013.0
Synthesis and antimicrobial activity of 4-hydroxy-4-(pyridyl)alk-3-en-2-ones
Bioorganic & Medicinal Chemistry 2009.0
Mechanism of unusual formation of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides and their antimicrobial evaluation
European Journal of Medicinal Chemistry 2009.0
Synthesis and antitumor activity of a series of sulfone analogs of 1,4-naphthoquinone
Journal of Medicinal Chemistry 1981.0
Synthesis, characterization and biological evaluation of some pyridine and quinoline fused chromenone derivatives
Medicinal Chemistry Research 2012.0
Ionic liquid catalyzed synthesis of 2-(indole-3-yl)-thiochroman-4-ones and their novel antifungal activities
Bioorganic & Medicinal Chemistry Letters 2015.0