Synthesis and antimicrobial activity of 4-hydroxy-4-(pyridyl)alk-3-en-2-ones
Bioorganic & Medicinal Chemistry
2009.0
Abstract
4-Hydroxy-4-(pyridyl)alk-3-en-2-ones were prepared by base-mediated condensation of ketones with pyridinecarboxylates. Several derivatives show weak antimicrobial activity against Gram-positive and Gram-negative bacteria.