Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues

Bioorganic & Medicinal Chemistry Letters
2009.0

Abstract

A series of thieno[3,2-b]pyrroloazepinones derivatives related to Hymenialdisine were prepared and tested for CHK1 inhibitory activity. Nanomolar inhibitions were achieved when electron-withdrawing substituents were introduced at position 3 of the thiophene ring.

Knowledge Graph

Similar Paper

Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues
Bioorganic & Medicinal Chemistry Letters 2009.0
Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis and biological evaluation of 2,6-disubstituted-9H-purine, 2,4-disubstitued-thieno[3,2-d]pyrimidine and -7H-pyrrolo[2,3-d]pyrimidine analogues as novel CHK1 inhibitors
European Journal of Medicinal Chemistry 2018.0
RETRACTED: Identification of novel aminothiazole and aminothiadiazole conjugated cyanopyridines as selective CHK1 inhibitors
European Journal of Medicinal Chemistry 2015.0
Synthesis and evaluation of novel anti-proliferative pyrroloazepinone and indoloazepinone oximes derived from the marine natural product hymenialdisine
European Journal of Medicinal Chemistry 2012.0
Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone
European Journal of Medicinal Chemistry 2008.0
Synthesis and evaluation of 5-substituted 9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as check point 1 kinase inhibitors
Bioorganic & Medicinal Chemistry 2010.0
Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2
Bioorganic & Medicinal Chemistry 2010.0
Fused-azepinones: Emerging scaffolds of medicinal importance
European Journal of Medicinal Chemistry 2021.0
Synthesis and Biological Activities of New Checkpoint Kinase 1 Inhibitors Structurally Related to Granulatimide
Journal of Medicinal Chemistry 2007.0