Discovery of a Potent Class I Selective Ketone Histone Deacetylase Inhibitor with Antitumor Activity in Vivo and Optimized Pharmacokinetic Properties

Discovery of a Potent Class I Selective Ketone Histone Deacetylase Inhibitor with Antitumor Activity in Vivo and Optimized Pharmacokinetic Properties Optimization of a series of potent and selective ketone histone deacetylase inhibitors A Novel Series of Potent and Selective Ketone Histone Deacetylase Inhibitors with Antitumor Activity in Vivo α-Mercaptoketone based histone deacetylase inhibitors Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model Trifluoromethyl ketones as inhibitors of histone deacetylase A series of novel, potent, and selective histone deacetylase inhibitors Heterocyclic ketones as inhibitors of histone deacetylase Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase Inhibitor Histone Deacetylase (HDAC) Inhibitors with a Novel Connecting Unit Linker Region Reveal a Selectivity Profile for HDAC4 and HDAC5 with Improved Activity against Chemoresistant Cancer Cells