Design and optimization of renin inhibitors: Orally bioavailable alkyl amines

Design and optimization of renin inhibitors: Orally bioavailable alkyl amines Optimization of orally bioavailable alkyl amine renin inhibitors Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors Discovery of highly potent renin inhibitors potentially interacting with the S3′ subsite of renin Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors