Synthesis of pochoxime prodrugs as potent HSP90 inhibitors

Bioorganic & Medicinal Chemistry Letters
2009.0

Abstract

Pochoximes are potent inhibitors of heat shock protein 90 (HSP90) based on the radicicol pharmacophores. Herein we present a pharmacokinetics and pharmacodynamics evaluation of this compound series as well as a phosphate prodrug strategy to facilitate formulation and improve oral bioavailability.

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